Clinical & Translational Research Home for Atlanta and Scientific Advances

From 2007 through 2016, this partnership has developed a Georgia "home" for clinical and translational research and has directly supported or contributed to 1,322 investigators; over 1,073 clinical interaction site projects and 270 pilot projects in 285 research areas; 386 federal (PHS) grants; 227 current or graduated MSCR, KL, or TL scholars and over 24 other active trainees. Direct support has also contributed to over 1,970 scientific publications.

ACTSI's most recent direct support of breakthroughs in cutting-edge clinical and translational research:

Pilot Awards

The Pilot Grants program has funded 269 grants thus far using $11.3 million in funding and 68 independent review cycles. The awards are divided between senior and junior PI investigators, and are distributed across all three ACTSI partner institutions, spanning a spectrum of translational research topics.

In collaboration with the Pilot Grants program, the Research Technologies program reviewed hundreds of applications in 12 independent cycles of request for applications, leading to the award of 23 pilot grants. The amount of each award ranged from $5,000 to $150,000, with the sum of funds totaling over $700,000. Awardees submitted seven extramural grant applications based on preliminary data derived from Research Technologies pilot grant support and five of these were funded, totaling $1.4 million.

Clinical Research Sites

Clinical Research Network (CRN) protocols have almost tripled since 2007. The CRN continues to establish sites throughout Atlanta, currently totaling 35 – the newest sites include the Georgia Tech Research Institute, the Emory Clinical & Translational Research Laboratory, and the Emory Integrated Genomics Core. In addition, the CRN was integral in the development of the inter-institutional Research Nursing Alliance which is dedicated to sharing ideas to improve the clinical research nursing practice, and has a mailing list of over 150 nurses from partner institutions who are dedicated to sharing ideas. The CRN developed and hosts the annual Clinical Practice of Human Subjects in Research seminar open to clinical professionals from all ACTSI partner institutions. CRN nurses continue to participate in the Preceptorship of nursing students in Emory's Nell Hodgson Woodruff School of Nursing's accelerated BSN program. CR-Assist, the CRN/BIP developed, web-based participant scheduling and tracking system received national attention from the CTSA Consortium. The CRN also recently completed an agreement with Emory Medical Labs to provide limited after-hours processing and provides support for the Laboratory Management System (LIMS) at the Hope Clinic, Ponce Center, Executive Health Program, Childrens Healthcare of Atlanta at Egleston, the Winship Cancer Center Phase 1 Unit, and Morehouse School of Medicine. Collaboration with Winship Cancer Institute (WCI) is strengthened by regular nursing support provided to the WCI Phase 1 Unit. CRN nurses also travel off-site to support more projects at the Emory Genetics Center and the Atlanta VA Medical Center. The CRN now offers expanded cardiovascular and exercise testing services at the Emory University Hospital site, including space for forearm vascular reactivity, exercise treadmills, pulmonary function testing, arterial infusion, and body composition using dual-energy x-ray absorptiometry (DEXA). Finally, the Recruitment Resource Core was developed to assist investigators with participant recruitment.

In conjunction with the Pediatrics program, the CRN is now able to support research activities at Hughes Spalding Children's Hospital. The CRN and Pediatrics program are working to increase support for outpatient protocols conducted at the Emory-Children's Center. Finally, "Community Health Matters" is a new newsletter developed by the CRN in collaboration with the Community Engagement Research Program (CERP) and distributed to the communities served by ACTSI.

Education & Training

Dawn Comeau, PhD, MPH, research associate professor, Emory Rollins School of Public Health Department of Behavioral Science and Health Eduction, and the ACTSI Research Education program evaluator, along with ACTSI colleagues published a paper entitled, “Improving clinical and translational research training: a qualitative evaluation of the Atlanta Clinical & Translational Science Institute KL2-mentored research scholars program” in the Journal of Investigative Medicine. The paper highlights the impact of the ACTSI KL2 program on career development of junior faculty at the ACTSI institutions.

The ACTSI Research Education Program scaled up formal mentor training for senior mentors of ACTSI-supported trainees as well as for junior faculty and ACTSI trainees in the Master of Science in Clinical Research (MSCR) and Certificate Program in Translational Research (CPTR) programs. The training workshops are based on curriculum from the National Research mentoring network (NRMN) funded by the NIH, and include training on the latest topics such as effective communication, fostering independence, equity and inclusion, and professional development. Participants reported that the training provides new approaches for promoting excellence in their trainees, new methods for handling challenging mentorship situations, and ideas on how to structure and evaluate mentoring relationships in the future. The modules can lead to time-saving and more efficient and effective relationships.

Pamela Bhatti, PhD, ACTSI Research Education former KL2 scholar and current member of the Research Education Executive Committee, partners with Georgia Tech Venture Lab to lead ACTSI investigators and trainees, as well as Centers for Disease Control & Prevention staff, through a process of customer/stakeholder discovery and business model generation. This evidence-based training methodology is guided by the National Science Foundation (NSF) I-Corps Program and the National Cancer Institute. Learn more about NIH ICorps | NSF ICorps

Three recent graduates of the KL2 program received NIH grants as a Principal Investigator:

Lucas McKay, PhD, MSCR, assistant professor of biomedical engineering, Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, received a K25 award for his work on neural mechanisms of balance deficits, falls, and freezing of gait in Parkinson’s disease.

Cecille Delille Lahiri, MD, MSCR, assistant professor, Department of Medicine, Division of Infectious Diseases,  Emory University School of Medicine, received a K23 award for her work on defining antiretroviral pharmacology within HIV-1 reservoirs of males and females.

Elizabeth Stenger, MD, MSCR, assistant professor in the division of Hematology/Oncology/BMT-Bone Marrow of the Department of Pediatrics, Emory University School of Medicine, received a K23 award for her work on improving haploidentical stem cell engraftment in sickle cell disease autologous mesenchymal stromal cells.

Former KL2 scholar Kisha Holden, PhD, MSc, associate professor of psychiatry and behavioral sciences, Morehouse School of Medicine, is deputy director of the Satcher Health Leadership Institute at Morehouse School of Medicine and is the PI of a $3M CDC Racial and Ethnic Approaches to Community Health (REACH) Award for transforming the metropolitan Atlanta communities through prevention, primary care linkages, and policy change. She also mentors a number of trainees at her research site.

Research Technologies

Research Technologies sponsors symposia which promote clinical and translational research and provide funding for the development of new and cutting-edge technologies. The newest partnership is with Women in Technology (WIT). Research Technologies supported a WIT Forum entitled “Exploring the ‘S’ in STEM” in 2016. Research Technologies continues to support Georgia Tech Capstone Design teams and Georgia Tech’s TI:GER program. Finally, the program also funded four $5,000 Medical Student Discovery Phase Mini-grants in 2016.

The Biomedical Informatics Program (BIP) supported the development of I2b2 which launched at Emory in October 2016. It includes data since January 2011 and is refreshed daily. BIP successfully tested Southeast SHRINE network (Emory, University of Alabama-Birmingham, University of Arkansas for Medical Science, and Medical University of South Carolina,) with demo data in winter 2016. Also, there is a six-module biomedical informatics massive online open course under development by Georgia Tech. BIP continues to support clinical and translational tools such as CR-Assist, REDCap, and Nautilus LIMS.


Pediatrics continues to build a citywide infrastructure for expanded pediatric-focused clinical and translational research within the ACTSI academic institutional partnerships.

ACTSI efforts led to the creation of a new and innovative pediatric clinical and translational research unit and continued engagement with Children's Healthcare of Atlanta. Over the past year, the ACTSI Pediatrics program supported 115 studies representing 18 various pediatric subspecialties for 924 research visits at the Pediatric Clinical Research Site within Egleston Children's Hospital. In conjunction with the CRN, ACTSI is now able to support research activities at Hughes Spaulding Children's Hospital. The CRN and Pediatrics programs have also increased their support for outpatient protocols conducted at the Emory-Children's Center (ECC) by opening the ECC-Research Unit (RU) in December 2015. To date, 40 studies representing 10 different divisions have utilized the unit for 339 visits. The space is operated by Emory University and offers an alternative research location for observational and minimal risk (no monitoring required) outpatient visits. 

Community Engagement

ACTSI Community Engagement Research Program (CERP) granted 26 community-academic research partnerships designed to foster and sustain community-engaged health initiatives, research, and effective dissemination strategies. Details associated with the CERP grant model, process, and outcomes may be found below:

  • Rogers, K, Akintobi, T., Thompson, W., Escoffery, C., Evans, D., & Kegler, M. (2014). A model for strengthening collaborative research capacity: Illustrations from the Atlanta Clinical Translational Science Institute. Health Education and Behavior, 41(3):267-274. PMID:24311741. Full-text
  • Kegler, M., Blumenthal, D., Henry Akintobi, T., Rodgers, K., Erwin, K., Thompson, W., Hopkins, E. (2016). Lessons learned from three models that use small grants for building academic-community partnerships for research. The Journal of Health Care for the Poor and the Underserved, 27(2), 527-548, PMID:27180693. Full-text
  • Henry Akintobi, T., Evans Wilkerson, D., Rodgers, K., Escoffery, C., Haardörfer, R., Kegler, M., (2016). Assessment of the Building Collaborative Research Capacity Model: Bridging the community-academic researcher divide. 6(2), 123-132. Full-text

ACTI-CERP sponsored two annual community engagement research forums drawing over 240 academic and community stakeholders. Nationally recognized keynote speakers included the National Community-Campus Partnerships for Health director (2014), NIMHHD CEHD (P20) director (2015), and the Satcher Health Leadership Institute founding director (2017).

Ethics & Regulatory

The program led enhancements of clinical research efficiencies through Atlanta-wide institutional agreements (e.g. IRB reciprocity and IP and Data Use agreements) and leadership of a comprehensive clinical trials improvement task force, the Healthcare Innovation Program (HIP), and Office of Clinical Research. Ethics & Regulatory's Online Ethics Center now includes over 40 ethical dilemmas in scientific research and expert opinions in PDF, video, and podcast formats. The program offers the ACTSI/Winship Cancer Institute Collaborative Ethics Consultation Service and the National CTSA Clinical Research Ethics Consultation Collaborative. The program also convened IRB officials from seven Atlanta research institutions in a first-of-its-kind meeting and co-created a cross institutional Electronic Conflict of Interest System (eCOI). Finally, IRB reciprocity and collaboration is improving throughout Atlanta as formal IRB reciprocity agreements now exist between all ACTSI partners.


ACTSI Success Stories
Search ACTSI Science Advance and Spotlight stories of success past and present here.

Creation of activities, such as the annual Academic & Industry Intersection Conference and device-focused pilot projects, that build strong partnerships with the private, non-profit Georgia Bio (encompassing the Georgia biotechnology community), the Coulter Foundation, and the state-sponsored Georgia Research Alliance to create synergies that foster and accelerate new and emerging technologies and discoveries.

Expansion of existing synergistic partnership with Yerkes National Primate Research Center on informatics, animal models, and educational opportunities.

Development of a growing partnership with the Winship Cancer Institute, a designated NCI Cancer Center, and collaborative efforts with Winship in genomics, a phase I clinical trials unit, joint pilot grants, and synergy with the Georgia Cancer Coalition and the Atlanta headquartered American Cancer Society.

Development of healthcare partnerships with the largest healthcare networks in Georgia including - Emory Healthcare, Children's Healthcare of Atlanta, Morehouse Medical Associates, Grady Health System, and Veterans Affairs Medical Center of Atlanta.

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